High-fidelity detection and analysis of all hair cell positions along the entire longitudinal axis of the organ of Corti were performed automatically by machine learning–based pattern recognition.
A sorbitol-based optical clearing method enabled imaging of the entire cochlea at subcellular resolution. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map of the organ of Corti. The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function.
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